{Reference Type}: Journal Article
{Title}: Real-World Treatment Patterns, Survival, and Economic Burden Among Elderly MCL Patients Previously Treated With cBTKis.
{Author}: Squires P;Puckett J;Ryland KE;Kamal-Bahl S;Raut M;Doshi J;Huntington SF;
{Journal}: Clin Lymphoma Myeloma Leuk
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 4
{Factor}: 2.822
{DOI}: 10.1016/j.clml.2024.05.023
{Abstract}: <B>BACKGROUND: </B>While covalent Bruton's tyrosine kinase inhibitors (cBTKis) have become a standard of care treatment for relapsed/refractory mantle cell lymphoma (R/R MCL), response duration is limited and resistance to BTKi and/or adverse events develop in a subset of patients. However, little real-world evidence on post-cBTKi clinical and economic outcomes exists for these patients.<BR><B>METHODS: </B>This retrospective study used 2010 to 2019 U.S. Medicare claims, to identify elderly (≥ 66 years) patients with newly-diagnosed MCL who received third-line (3L) treatment and had evidence of cBTKi use in a prior line of therapy. Outcomes were assessed ≥ 12-months post 3L-treatment initiation and included treatment patterns, all-cause and MCL-related HRU and costs, and overall survival.<BR><B>RESULTS: </B>The final sample contained 230 elderly patients with R/R MCL receiving 3L treatment who had cBTKi use in a prior line of therapy (mean age 75.0, 21.7% age > 80 years; 67.4% male; 93.9% White). Common 3L treatments included chemotherapy (26.1%), lenalidomide (18.7%), and bortezomib (18.3%); 1-quarter (25.7%) of patients received a cBTKi (17.8% ibrutinib; 7.8% acalabrutinib). Overall survival was poor from 3L treatment initiation (median OS = 9.4 months; 1-years survival rate = 43.7%). Patients exhibited high rates of HRU (73.6% experienced hospitalization) and substantial costs ($145,726) in the 12-months after 3L initiation.<BR><B>CONCLUSIONS: </B>A large unmet need exists in this patient subpopulation, highlighting the importance of ongoing development of novel therapeutics.