{Reference Type}: Journal Article
{Title}: EEG for good outcome prediction after cardiac arrest: A multicentre cohort study.
{Author}: Turella S;Dankiewicz J;Ben-Hamouda N;Bernhard Nilsen K;Düring J;Endisch C;Engstrøm M;Flügel D;Gaspard N;Grejs AM;Haenggi M;Haffey S;Imbach L;Johnsen B;Kemlink D;Leithner C;Legriel S;Lindehammar H;Mazzon G;Nielsen N;Peyre A;Ribalta Stanford B;Roman-Pognuz E;Rossetti AO;Schrag C;Valeriánová A;Wendel-Garcia P;Zubler F;Cronberg T;Westhall E; ;
{Journal}: Resuscitation
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 17
{Factor}: 6.251
{DOI}: 10.1016/j.resuscitation.2024.110319
{Abstract}: <B>OBJECTIVE: </B>Assess the prognostic ability of a non-highly malignant and reactive EEG to predict good outcome after cardiac arrest (CA).<BR><B>METHODS: </B>Prospective observational multicentre substudy of the "Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest Trial", also known as the TTM2-trial. Presence or absence of highly malignant EEG patterns and EEG reactivity to external stimuli were prospectively assessed and reported by the trial sites. Highly malignant patterns were defined as burst-suppression or suppression with or without superimposed periodic discharges. Multimodal prognostication was performed 96 h after CA. Good outcome at 6 months was defined as a modified Rankin Scale score of 0-3.<BR><B>RESULTS: </B>873 comatose patients at 59 sites had an EEG assessment during the hospital stay. Of these, 283 (32%) had good outcome. EEG was recorded at a median of 69 h (IQR 47-91) after CA. Absence of highly malignant EEG patterns was seen in 543 patients of whom 255 (29% of the cohort) had preserved EEG reactivity. A non-highly malignant and reactive EEG had 56% (CI 50-61) sensitivity and 83% (CI 80-86) specificity to predict good outcome. Presence of EEG reactivity contributed (p < 0.001) to the specificity of EEG to predict good outcome compared to only assessing background pattern without taking reactivity into account.<BR><B>CONCLUSIONS: </B>Nearly one-third of comatose patients resuscitated after CA had a non-highly malignant and reactive EEG that was associated with a good long-term outcome. Reactivity testing should be routinely performed since preserved EEG reactivity contributed to prognostic performance.