{Reference Type}: Journal Article
{Title}: Blocking smoothened cholesterylation: A strategy for overcoming drug resistance in cancer.
{Author}: Cheng SY;Zhang YE;
{Journal}: Cell Chem Biol
{Volume}: 31
{Issue}: 7
{Year}: 2024 Jul 18
{Factor}: 9.039
{DOI}: 10.1016/j.chembiol.2024.06.005
{Abstract}: In this issue of Cell Chemical Biology, Liu et al.1 report the identification of Q29, a synthetic diterpenoid that blocks covalent cholesterol modification of smoothened (SMO) and inhibits hedgehog signaling. Q29 is capable of suppressing tumor cell growth, both in vitro and in vivo, and overcoming resistance to SMO inhibitors.