{Reference Type}: Journal Article
{Title}: Highly selective Zn2+ near-infrared fluorescent probe and its application in biological imaging.
{Author}: Song Q;Bai C;Dong Y;Chen M;Wang S;Hu J;Qiao X;Chen J;Li S;Liu X;Wang X;Qiao R;Qu C;Miao H;
{Journal}: Spectrochim Acta A Mol Biomol Spectrosc
{Volume}: 322
{Issue}: 0
{Year}: 2024 Dec 5
{Factor}: 4.831
{DOI}: 10.1016/j.saa.2024.124828
{Abstract}: Zn2+ plays a vital role in regulating various life processes, such as gene expression, cell signaling, and brain function. In this study, a near-infrared fluorescent probe AXS was synthesized to detect Zn2+ with good fluorescence specificity, high selectivity, and high sensitivity; the detection limit of Zn2+ was 6.924 × 10-11 M. The mechanism of Zn2+ recognition by the AXS probe was investigated by 1H nuclear magnetic resonance titrations, UV-visible spectroscopy, fluorescence spectroscopy, Fourier-transform infrared spectroscopy, and high-resolution mass spectrometry. Test paper experiments showed that the AXS probe could detect Zn2+ in real samples. In addition, quantitative and qualitative detection of Zn2+ in common foodstuffs was achieved. For portable Zn2+ detection, a smartphone detection platform was also developed based on the AXS probe. Importantly, the AXS probe showed good bioimaging capabilities in Caenorhabditis elegans and mice.