{Reference Type}: Case Reports {Title}: A rare case of Gynura-segetum-related hepatic sinus obstruction syndrome complicated with alcoholic liver disease. {Author}: Gao Y;Zhang X;Zhou X;Wang J;Gong L;Chen G; {Journal}: J Pak Med Assoc {Volume}: 74 {Issue}: 7 {Year}: 2024 Jul {Factor}: 1.002 {DOI}: 10.47391/JPMA.9296 {Abstract}: Hepatic sinus obstruction syndrome (HSOS) is easy to be misdiagnosed or missed, and there is no unified and effective treatment for it. A patient was considered to have Budd-Chiari syndrome. He underwent a transjugular liver biopsy, and pathological examination revealed HSOS without liver cirrhosis. After the failure of anticoagulation therapy, he successfully received a transjugular intrahepatic portosystemic shunt (TIPS). After discharge, he was followed-up for four years with a good prognosis. G. segetum-induced HSOS can be easily overlooked, especially in patients with underlying liver diseases. When medical therapy fails, TIPS can control ascites and portal hypertension, and the long-term prognosis is optimistic.