{Reference Type}: Journal Article
{Title}: Choroidal Thickness in Mild Autonomous Cortisol Secretion.
{Author}: Cakir SD;Cakir A;Ozturk FY;Basmaz SE;Batman A;Saygili ES;Erol RS;Sen EC;Canat MM;Altuntas Y;
{Journal}: Sisli Etfal Hastan Tip Bul
{Volume}: 58
{Issue}: 2
{Year}: 2024
暂无{DOI}: 10.14744/SEMB.2024.12258
{Abstract}: <B>UNASSIGNED: </B>To evaluate the patients with mild autonomous cortisol secretion (MACS) by means of choroidal thickness (CT) and also investigate whether CT may be a diagnostic tool in the management of MACS or not.<BR><B>UNASSIGNED: </B>Twenty-seven patients with MACS and 25 age-sex-matched healthy controls were enrolled in this cross-sectional comparative study. All the participants underwent CT measurement by using Spectralis optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany) with enhanced deep imaging mode at the subfoveal, 500-1000-1500 µm nasal and 500-1000-1500 µm temporal to the foveola.<BR><B>UNASSIGNED: </B>The groups were similar in terms of spherical equivalence, age and axial lengths. The mean CT was significantly thicker in patients with MACS than controls in all measurement quadrants (p<0.001). There was no significant correlation between CT, size of the adenoma, basal cortisol, 1mg dexamethasone suppression test, salivary cortisol, 24-hour total urine-free cortisol, ACTH and DHEAS levels. However, 2 mg dexamethasone suppression test results were found to be significantly correlated with CT in temporal 500-1000 and 1500 µm quadrants (r=0.436, p=0.023, r=0.443, p=0.021 and r=0.488, p=0.010, respectively). Five (18.5%) eyes had pachychoroid pigment epitheliopathy in the MACS group.<BR><B>UNASSIGNED: </B>CT increases in patients with MACS and those tend to have pachychoroid pigment epitheliopathy more frequent than healthy individuals. A thicker choroid in the patients with MACS may be a novel biomarker both as a diagnostic tool for the degree of hypercortisolemia and cortisol-related comorbidity.