{Reference Type}: Journal Article
{Title}: High-grade serous ovarian cancer (HGSOC) with fallopian tube involvement.
{Author}: Tănase AE;Solomon-Condriuc IP;Mogoş RA;Costăchescu G;David C;Buzdugă CM;Scripcariu DV;Costea CF;Cucu AI;Tănase GV;Tănase DM;Nemescu D;Dumitrescu AM;Cărăuleanu A;
{Journal}: Rom J Morphol Embryol
{Volume}: 65
{Issue}: 2
{Year}: 2024 Apr-Jun
{Factor}: 0.833
{DOI}: 10.47162/RJME.65.2.20
{Abstract}: <B>BACKGROUND: </B>Literature data present new studies about precancerous lesions of pelvic serous carcinoma that originate from the tubal secretory cells. It has long been thought that ovarian cancer cannot be prevented by prophylactic screening or surgery. In recent years, gynecologists have adapted to new principles and so, during routine hysterectomies in perimenopausal women for benign uterine pathologies, salpingo-oophorectomy is performed as a prophylactic approach.<BR><B>OBJECTIVE: </B>The purpose of our article was to draw attention to the association between abnormal fallopian tube pathology and the presence of serous ovarian neoplasia in perimenopausal women at risk.<BR><B>METHODS: </B>We report the case of a 45-year-old woman who had unspecific symptoms of abdominal pain and loss of appetite and weight. A pelvic magnetic resonance imaging was performed, and an ovarian mass was detected. Our case shows that the fallopian tube can be the primary point of origin for a pelvic disease, therefore prevention is possible with early computed tomography scan and annual ultrasound. The patient presented with a T1c staging post-surgery and her chances of survival could have decreased if she had postponed medical examination longer. We found a significant increase in the absolute number of tubal secretory cells in patients with ovarian neoplasia, which supports the assumption that serous tubal intraepithelial carcinoma lesions are found especially in the serous ovarian type.<BR><B>CONCLUSIONS: </B>Our article is a strong suggestion that serous ovarian cancer originates from the fallopian tube and can potentially serve as a sensitive biomarker for early serous carcinogenesis within the fallopian tube.