{Reference Type}: Journal Article
{Title}: Primary amine-catalyzed enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones to α,β-unsaturated ketones.
{Author}: Goyal P;Dubey AK;Chowdhury R;Wadawale A;
{Journal}: Beilstein J Org Chem
{Volume}: 20
{Issue}: 0
{Year}: 2024
{Factor}: 2.544
{DOI}: 10.3762/bjoc.20.136
{Abstract}: The enantioselective 1,4-addition reaction of pyrazolin-5-ones to α,β-unsaturated ketones catalyzed by a cinchona alkaloid-derived primary amine-Brønsted acid composite is reported. Both enantiomers of the anticipated pyrazole derivatives were obtained in good to excellent yields (up to 97%) and high enantioselectivities (up to 98.5% ee) under mild reaction conditions. In addition, this protocol was further expanded to synthesize highly enantioenriched hybrid molecules bearing biologically relevant heterocycles.