{Reference Type}: Journal Article
{Title}: Synthesis and biological evaluation of vioprolide B and its dehydrobutyrine-glycine analogue.
{Author}: Osorio Reineke N;Elsen FAV;Grab HA;Mostert D;Sieber SA;Bach T;
{Journal}: Chem Commun (Camb)
{Volume}: 60
{Issue}: 63
{Year}: 2024 Aug 1
{Factor}: 6.065
{DOI}: 10.1039/d4cc02946a
{Abstract}: Herein, we describe the total synthesis of the depsipeptide vioprolide B and of an analogue, in which the (E)-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.