{Reference Type}: Journal Article
{Title}: Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat fMRI study.
{Author}: Chen S;Li B;Hu Y;Zhang Y;Dai W;Zhang X;Zhou Y;Su D;
{Journal}: CNS Neurosci Ther
{Volume}: 30
{Issue}: 7
{Year}: 2024 Jul
{Factor}: 7.035
{DOI}: 10.1111/cns.14866
{Abstract}: <B>BACKGROUND: </B>Reversible loss of consciousness is the primary therapeutic endpoint of general anesthesia; however, the drug-invariant mechanisms underlying anesthetic-induced unconsciousness are still unclear. This study aimed to investigate the static, dynamic, topological and organizational changes in functional brain network induced by five clinically-used general anesthetics in the rat brain.<BR><B>METHODS: </B>Male Sprague-Dawley rats (n = 57) were randomly allocated to received propofol, isoflurane, ketamine, dexmedetomidine, or combined isoflurane plus dexmedetomidine anesthesia. Resting-state functional magnetic resonance images were acquired under general anesthesia and analyzed for changes in dynamic functional brain networks compared to the awake state.<BR><B>RESULTS: </B>Different general anesthetics induced distinct patterns of functional connectivity inhibition within brain-wide networks, resulting in multi-level network reorganization primarily by impairing the functional connectivity of cortico-subcortical networks as well as by reducing information transmission capacity, intrinsic connectivity, and network architecture stability of subcortical regions. Conversely, functional connectivity and topological properties were preserved within cortico-cortical networks, albeit with fewer dynamic fluctuations under general anesthesia.<BR><B>CONCLUSIONS: </B>Our findings highlighted the effects of different general anesthetics on functional brain network reorganization, which might shed light on the drug-invariant mechanism of anesthetic-induced unconsciousness.