{Reference Type}: Journal Article
{Title}: Association between dietary riboflavin intake and cognitive decline in older adults: a cross-sectional analysis.
{Author}: Zhang K;Cai T;Han Y;Gu Z;Hu R;Hou Z;Yu X;Gao Y;Gao M;Liu T;Zhang Y;
{Journal}: Nutr Neurosci
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 16
{Factor}: 4.062
{DOI}: 10.1080/1028415X.2024.2375171
{Abstract}: <B>UNASSIGNED: </B>Research exploring the link between dietary riboflavin intake and cognitive decline in this demographic is limited. Our aim was to examine the association between riboflavin intake levels and cognitive decline.<BR><B>UNASSIGNED: </B>The National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2014 were utilized in this cross-sectional analysis. The Consortium to Establish a Registry for Alzheimer's Disease test Word Learning delayed recall trial (DR), Digit Symbol Substitution Test (DSST), Animal Fluency Test(AFT) and Z test were used to evaluate cognitive performance. Multivariate logistic regression, restricted cubic spline and subgroup analysis were performed to evaluate the associations between riboflavin intake and cognitive decline.<BR><B>UNASSIGNED: </B>The study included a total of 2255 patients, with 47.9% being male. The incidence of cognitive decline was 23.8%. After adjusting for all selected covariates, we found that high riboflavin intake was associated with a lower risk of cognitive impairment in adults in the United States. When riboflavin intake was used as a Categorical variable, compared to those with the lowest intake, the odds ratio (OR) of individuals with the highest riboflavin intake for DR test, AFT test, DSST test and Z test were 0.73 (95% CI: 0.53~1), 0.68(95% CI: 0.49-0.96),0.53(95% CI: 0.37-0.77) and 0.56(95% CI: 0.39-0.8). The study also found an L-shaped association between riboflavin intake and cognitive decline, with an inflection point at approximately 2.984 mg/d.<BR><B>UNASSIGNED: </B>Our cross-sectional study in a nationwide sample of American old adults suggests that dietary riboflavin intake was negative associated with cognitive decline.