{Reference Type}: Journal Article
{Title}: Occult residual ovarian tissue at the time of minimally invasive risk reducing surgery in women with BRCA mutations.
{Author}: Polan RM;Ali-Fehmi R;Grace AK;Mattei LH;Tanner EJ;Morris RT;
{Journal}: Gynecol Oncol
{Volume}: 189
{Issue}: 0
{Year}: 2024 Jul 13
{Factor}: 5.304
{DOI}: 10.1016/j.ygyno.2024.07.005
{Abstract}: <B>OBJECTIVE: </B>To describe extension of ovarian tissue beyond visible and National Comprehensive Cancer Network recommended margins among patients with BRCA mutations undergoing minimally invasive risk-reducing salpingo-oophorectomy.<BR><B>METHODS: </B>A prospective study of patients with BRCA mutations who underwent minimally invasive risk-reducing bilateral salpingo-oophorectomy was conducted. Patient enrollment occurred between October 2021 and 2023. Tissue specimens were analyzed according to the Sectioning and Extensively Examining the Fimbriated End protocol.<BR><B>RESULTS: </B>Twenty women with BRCA mutations were prospectively enrolled. All patients underwent minimally invasive surgery with 70% undergoing concurrent hysterectomy (n = 14). Approximately half of these procedures were performed with robotic assistance (n = 9, 45%). One patient was admitted overnight (5%); the other nineteen were discharged on the day of surgery (95%). One patient experienced a major complication and required readmission (5%). Extension of ovarian tissue beyond the visible ovary was noted on pathologic examination of six specimens (30%). In one patient this was observed on the left (17%), in three on the right (50%), and in two bilateral extension (33%) was noted. The distance ovarian stroma extended microscopically beyond the visible ovary was between 2 and 14 mm, with a median of 5 mm. Among patients with microscopic extension of ovarian tissue, the majority (n = 5, 83%) had a BRCA2 mutation.<BR><B>CONCLUSIONS: </B>In women with BRCA mutations undergoing risk-reducing minimally invasive surgery, approximately one third had microscopic extension of ovarian stroma beyond the visible ovary. Current guidelines which recommend resection of at least 20 mm of tissue beyond the visible ovary are likely adequate in this population.