{Reference Type}: Journal Article
{Title}: Au NPs modified Ni-B nanosheets/graphene oxide three-dimensional network as label-free electrochemical immunosensor for the detection of diethylstilbestrol.
{Author}: Shen Q;Ding J;Guo Z;Yang X;Zhang Y;Xu B;Yang H;Sun Y;Hang L;
{Journal}: Bioelectrochemistry
{Volume}: 160
{Issue}: 0
{Year}: 2024 Jul 11
{Factor}: 5.76
{DOI}: 10.1016/j.bioelechem.2024.108778
{Abstract}: Three-dimensional (3D) network provide a promising platform for construction of high sensitive electrochemical immunosensor due to the benefits of high specific surface area and electron mobility. Herein, a sensitive label-free electrochemical immunosensor based on Au nanoparticles modified Ni-B nanosheets/graphene matrix was constructed to detect diethylstilbestrol (DES). The 3D network not only could increase the electron transport rate and surface area, but also could provide confinement area, which is conducive to increases the collision frequency with the active site. Moreover, Au NPs also have good biocompatibility, which is beneficial for ligating antibodies. Benefiting from the 3D network structure and Au collective effect, the electrochemical immunosensor possess sterling detection ability with wide linear response range (0.00038-150 ng/mL) and low detection limit (31.62 fg/mL). Moreover, the constructed immunosensor can also be extend to detect DES in Tap-water and river water. This work may provide a novel material model for the construction of high sensitive immunosensor.