{Reference Type}: Journal Article
{Title}: NMDAR dysfunction and the regulation of dopaminergic transmission in schizophrenia.
{Author}: Dwyer GE;Johnsen E;Hugdahl K;
{Journal}: Schizophr Res
{Volume}: 271
{Issue}: 0
{Year}: 2024 Jul 12
{Factor}: 4.662
{DOI}: 10.1016/j.schres.2024.07.025
{Abstract}: A substantial body of evidence implicates dysfunction in N-methyl-d-aspartate receptors (NMDARs) in the pathophysiology of schizophrenia. This article illustrates how NMDAR dysfunction may give rise to many of the neurobiological phenomena frequently associated with schizophrenia with a particular focus on how NMDAR dysfunction affects the thalamic reticular nucleus (nRT) and pedunculopontine tegmental nucleus (PPTg). Furthermore, this article presents a model for schizophrenia illustrating how dysfunction in the nRT may interrupt prefrontal regulation of midbrain dopaminergic neurons, and how dysfunction in the PPTg may drive increased, irregular burst firing.