{Reference Type}: Journal Article
{Title}: Pills of Multi-Target H2S Donating Molecules for Complex Diseases.
{Author}: Corvino A;Scognamiglio A;Fiorino F;Perissutti E;Santagada V;Caliendo G;Severino B;
{Journal}: Int J Mol Sci
{Volume}: 25
{Issue}: 13
{Year}: 2024 Jun 27
{Factor}: 6.208
{DOI}: 10.3390/ijms25137014
{Abstract}: Among the various drug discovery methods, a very promising modern approach consists in designing multi-target-directed ligands (MTDLs) able to modulate multiple targets of interest, including the pathways where hydrogen sulfide (H2S) is involved. By incorporating an H2S donor moiety into a native drug, researchers have been able to simultaneously target multiple therapeutic pathways, resulting in improved treatment outcomes. This review gives the reader some pills of successful multi-target H2S-donating molecules as worthwhile tools to combat the multifactorial nature of complex disorders, such as inflammatory-based diseases and cancer, as well as cardiovascular, metabolic, and neurodegenerative disorders.