{Reference Type}: Journal Article {Title}: Aortic Regurgitation in Bicuspid Aortic Valve: The Role of Multimodality Imaging. {Author}: La Mura L;Lembo M;Musella F;D'Amato M;D'Andrea A;Izzo R;Esposito G; {Journal}: J Clin Med {Volume}: 13 {Issue}: 13 {Year}: 2024 Jul 4 {Factor}: 4.964 {DOI}: 10.3390/jcm13133924 {Abstract}: The evaluation of aortic regurgitation (AR) in bicuspid valve (BAV) is still a challenge because of the eccentricity of the jet, which may under/overestimate the regurgitation. The commonly used echocardiography parameters (such as vena contracta, pressure half-time, etc.) may not be useful in this kind of patient. A multimodality approach combining echocardiography, cardiac MRI, cardiac CT, and advanced technologies applied to non-invasive cardiac imaging (e.g., 4D flow and strain imaging) may be useful to better quantify regurgitation and to select patients suitable for valve replacement. This review provides an overview of the most recent insights about cardiovascular imaging tools and their utility in BAV evaluation, focusing on chronic regurgitation. We describe the role of multimodality imaging in both diagnosis and risk assessment of this disease, pointing out the advantages and disadvantages of the imaging techniques, aiming to provide a guide to clinicians and cardiovascular imaging specialists in choosing the best imaging tools to use.