{Reference Type}: Journal Article {Title}: Pyoderma Gangrenosum, a Challenging Postpartum Diagnosis-Case Report and Literature Review. {Author}: Matasariu DR;Bujor IE;Mihălceanu E;Gîscă TC;Stâncanu A;Andriescu EC;Popescu I;Socolov D;Vasiluță C;Ursache A; {Journal}: J Clin Med {Volume}: 13 {Issue}: 13 {Year}: 2024 Jun 22 {Factor}: 4.964 {DOI}: 10.3390/jcm13133653 {Abstract}: Background/Objectives: The infrequent occurrence of pyoderma gangrenosum (PG) during pregnancy and in postpartum, with its subsequent diagnostic intricacies, caused us to present the following case. Methods: This article describes a rare case of PG in postpartum in a patient without any prior pathology and a short review of the literature, aiming to identify similar rare instances. Results: We conducted a literature review to ascertain the prevalence of postpartum pyoderma gangrenosum, and we identified a total of 41 cases. Conclusions: Our article underlines again the importance of interdisciplinary collaboration for the prompt identification and commencement of necessary therapeutic interventions in postpartum women afflicted by pyoderma gangrenosum.