{Reference Type}: Journal Article
{Title}: An atlas of causal association between micronutrients and osteoarthritis.
{Author}: Wei W;Qi X;Cheng B;He D;Qin X;Zhang N;Zhao Y;Chu X;Shi S;Cai Q;Yang X;Cheng S;Meng P;Hui J;Pan C;Zhao B;Liu L;Wen Y;Liu H;Jia Y;Zhang F;
{Journal}: Prev Med
{Volume}: 185
{Issue}: 0
{Year}: 2024 Aug 10
{Factor}: 4.637
{DOI}: 10.1016/j.ypmed.2024.108063
{Abstract}: OBJECTIVE: This study examines the causal relationships between serum micronutrients and site-specific osteoarthritis (OA) using Mendelian Randomization (MR).
METHODS: This study performed a two-sample MR analysis to explore causal links between 21 micronutrients and 11 OA outcomes. These outcomes encompass overall OA, seven site-specific manifestations, and three joint replacement subtypes. Sensitivity analyses using MR methods, such as the weighted median, MR-Egger, and MR-PRESSO, assessed potential horizontal pleiotropy and heterogeneity. Genome-wide association summary statistical data were utilized for both exposure and outcome data, including up to 826,690 participants with 177,517 OA cases. All data was sourced from Genome-wide association studies datasets from 2009 to 2023.
RESULTS: In the analysis of associations between 21 micronutrients and 11 OA outcomes, 15 showed Bonferroni-corrected significance (P < 0.000216), without significant heterogeneity or horizontal pleiotropy. Key findings include strong links between gamma-tocopherol and spine OA (OR = 1.70), and folate with hand OA in finger joints (OR = 1.15). For joint replacements, calcium showed a notable association with a reduced likelihood of total knee replacement (TKR) (OR = 0.52) and total joint replacement (TJR) (OR = 0.56). Serum iron was significantly associated with an increased risk of total hip replacement (THR) (OR = 1.23), while folate indicated a protective effect (OR = 0.95). Various sex-specific associations were also uncovered.
CONCLUSIONS: These findings underscore the critical role of micronutrients in osteoarthritis, providing valuable insights for preventive care and potential enhancement of treatment outcomes.