{Reference Type}: Journal Article
{Title}: Long-term exposure to prometryn damages the visual system and changes color preference of female zebrafish (Danio rerio).
{Author}: Wei S;Yang Y;Zong Y;Yang Y;Guo M;Zhang Z;Zhang R;Ru S;Zhang X;
{Journal}: Chemosphere
{Volume}: 363
{Issue}: 0
{Year}: 2024 Sep 11
{Factor}: 8.943
{DOI}: 10.1016/j.chemosphere.2024.142835
{Abstract}: Color vision, initiated from the cone photoreceptors, is essential for fish to obtain environmental information. Although the visual impairment of triazine herbicide prometryn has been reported, data on the effect of herbicide such as prometryn on natural color sensitivity of fish is scarce. Here, zebrafish were exposed to prometryn (0, 1, 10, and 100 μg/L) from 2 h post-fertilization to 160 days post-fertilization, to explore the effect and underlying mechanism of prometryn on color perception. The results indicated that 10 and 100 μg/L prometryn shortened the height of red-green cone cells, and down-regulated expression of genes involved in light transduction pathways (arr3a, pde6h) and visual cycle (lrata, rpe65a); meanwhile, 1 μg/L prometryn increased all-trans-retinoic acid levels in zebrafish eyes, and up-regulated the expression of genes involved in retinoid metabolism (rdh10b, aldh1a2, cyp26a1), finally leading to weakened red and green color perception of female zebrafish. This study first clarified how herbicide such as prometryn affected color vision of a freshwater fish after a long-term exposure from both morphological and functional disruption, and its hazard on color vision mediated-ecologically relevant tasks should not be ignored.