{Reference Type}: Case Reports
{Title}: Ichthyosis uteri complicated by endometrial adenocarcinoma with transitional cell differentiation: A case report.
{Author}: Ding L;Liu W;Li H;Huang D;Chen Y;An H;
{Journal}: Medicine (Baltimore)
{Volume}: 103
{Issue}: 28
{Year}: 2024 Jul 12
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000038792
{Abstract}: <B>BACKGROUND: </B>Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare.<BR><B>METHODS: </B>A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus.<BR><B>METHODS: </B>Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia.<BR><B>METHODS: </B>Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy.<BR><B>RESULTS: </B>Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis.<BR><B>CONCLUSIONS: </B>Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.