{Reference Type}: Journal Article
{Title}: The role of CD83 in the pathogenesis of immune thrombocytopenia.
{Author}: Wang X;Zhou Q;Yang W;Bi H;Wang H;Wang Y;Du Y;Liu L;Liu Y;Yin L;Yao J;Yu J;Tao W;Zhou Y;Zhou Z;
{Journal}: Hematology
{Volume}: 29
{Issue}: 1
{Year}: 2024 Dec
{Factor}: 2.264
{DOI}: 10.1080/16078454.2024.2372482
{Abstract}: <B>UNASSIGNED: </B>CD83 are closely related to the pathogenesis of immune thrombocytopenia (ITP), but the exact mechanism remains unclear.<BR><B>UNASSIGNED: </B>To explore the relationship between CD83 and CD4+ T cell subsets and clarify the role of CD83 in the pathogenesis of ITP.<BR><B>UNASSIGNED: </B>RT-qPCR and Flow cytometry were used to illustrate CD83 expression. The downregulation and overexpression of DC-CD83 were co-cultured with CD4+ T cells to detect cell proliferation, co-cultured supernatant cytokines and Tregs expression.<BR><B>UNASSIGNED: </B>The results indicate that the ITP patients showed higher expression of CD83 than the healthy controls. The proliferation of CD4+ T cells was inhibited by downregulation of DCs-CD83 but promoted by overexpression of DCs-CD83. siRNA-CD83 inhibited proinflammatory IFN-γ and IL-17 secretion while raising TGF-β, IL-10 concentrations. Overexpression of DCs-CD83 promoted Tregs expression.<BR><B>UNASSIGNED: </B>The Th1/Th2 and Th17/Tregs polarization were reversed via interfering DCs with siRNA-CD83. CD83 plays an important role in ITP pathogenesis, suggesting novel treatment for ITP patients.