{Reference Type}: Journal Article
{Title}: Identification of an Exosome-relevant SNHG6-hsa-miR-429- CHRDL1/CCNA2 Axis for Lung Adenocarcinoma Prognosis Evaluation.
{Author}: Yuan Y;Li Q;Chen F;Zhao Y;Ma J;Fang S;
{Journal}: Curr Med Chem
{Volume}: 31
{Issue}: 28
{Year}: 2024 Nov 23
{Factor}: 4.74
{DOI}: 10.2174/0109298673280925231122104717
{Abstract}: <B>OBJECTIVE: </B>To explore an exosome-relevant molecular classification in lung adenocarcinoma (LUAD).<BR><B>BACKGROUND: </B>Exosome genes or relevant non-coding RNAs are regulators of cancer treatment and prognosis, but their function in LUAD has not yet been determined.<BR><B>OBJECTIVE: </B>Unraveling a molecular classification applying exosome-related RNA networks for LUAD prognosis evaluation.<BR><B>METHODS: </B>MicroRNA sequencing data (miRNAs-seq) and RNA sequencing data (RNA- seq) were derived from The Cancer Genome Atlas (TCGA). The ConsensusCluster- Plus package was used for molecular typing in LUAD based on 121 Exosome-related genes. Then, a limma package was conducted to explore differentially expressed mRNAs (DEmRNAs), differentially expressed miRNAs (DEmiRNAs) and differentially expressed lncRNAs (DElncRNAs) in molecular typing for constructing an Exosome-driven competing endogenous RNA network (ceRNA). Dominant miRNAs, as well as target mRNAs, were identified by COX modeling and Kaplan-Meier survival analysis.<BR><B>RESULTS: </B>Two Exosome-associated molecular clusters classified in LUAD. The C2 cluster favored high clinicopathology and showed a trend toward poor prognosis. 29 lncRNA- miRNA and 12 miRNA-mRNA interaction pairs were identified. The hsa-miR-429 was the pivotal miRNA in the network that affected the prognosis of LUAD. According to the interaction relationship and LUAD prognostic role, SNHG6-hsa- miR-429-CHRDL1/CCNA2 was identified. SNHG6-hsa-miR-429-CHRDL1 exerts oncogenic effects, and SNHG6-hsa-miR-429- CCNA2 exerts pro-oncogenic effects.<BR><B>CONCLUSIONS: </B>Overall, our study identified an Exosome-driven ceRNA network in LUAD, and the SNHG6-hsa-miR-429-CHRDL1/CCNA2 axis could be a new therapeutic target for LUAD and our study provides new insights into the molecular mechanisms of LUAD.