{Reference Type}: Journal Article
{Title}: Sensitivity and Specificity in Urine Bladder Cancer Markers - Is it that Simple?
{Author}: Roghmann F;Goebell PJ;Dyrskjøt L;van Rhijn BWG;Käfferlein HU;Hakenberg O;Stenzl A;Burger M;Pesch B;Benderska-Söder N;Schmitz-Dräger BJ;
{Journal}: Bladder Cancer
{Volume}: 8
{Issue}: 1
{Year}: 2022
{Factor}: 1.449
{DOI}: 10.3233/BLC-211602
{Abstract}: Marker research, and in particular urine bladder cancer marker research throughout the past three decades, devours enormous scientific resources in terms of manpower (not to mention time spent on reviewing and editorial efforts) and financial resources, finally generating large numbers of manuscripts without affecting clinical decision making. This is mirrored by the fact that current guidelines do not recommend marker use due to missing level 1 evidence. Although we recognize the problems and obstacles, the authors of this commentary feel that the time has come to abandon the current procedures and move on to prospective trial designs implementing marker results into clinical decision making. Our thoughts and concerns are summarized in this comment.