{Reference Type}: Journal Article
{Title}: The value of pre-transplant coronary angiography findings in kidney transplant candidates at high risk for cardiovascular disease.
{Author}: Morená L;Al Jurdi A;Adam EL;Verhoeff R;Palsson R;Ribas GT;Hullekes F;Cohen Bucay A;Elias N;Riella LV;
{Journal}: Front Transplant
{Volume}: 2
{Issue}: 0
{Year}: 2023
暂无{DOI}: 10.3389/frtra.2023.1304516
{Abstract}: <B>UNASSIGNED: </B>Cardiovascular disease is a significant cause of mortality after kidney transplantation. Whether pre-transplant screening for coronary artery disease (CAD) in asymptomatic kidney transplant candidates (KTCs) is beneficial is unclear.<BR><B>UNASSIGNED: </B>We conducted a retrospective cohort study evaluating post-transplant cardiovascular events in 192 high-risk KTCs who underwent pre-transplant CAD evaluation. The study aimed to identify risk factors associated with finding severe CAD on pre-transplant angiography, and to assess the relationship between screening strategies and post-transplant cardiovascular events.<BR><B>UNASSIGNED: </B>At five years post-transplant, cardiovascular events occurred in 23.9% of subjects. Prior CAD history and left ventricular ejection fraction (LVEF) < 50% were associated with higher odds of finding severe CAD on pre-transplant angiography. Severe CAD on angiography was associated with a higher risk of early cardiovascular events within six months of transplantation. However, coronary intervention in KTCs with severe CAD was not associated with lower rates of post-transplant cardiovascular events.<BR><B>UNASSIGNED: </B>Pre-transplant coronary angiography to identify severe CAD is of highest yield in KTCs with a history of CAD or an LVEF < 50%. Our findings indicate that the identification of severe CAD in KTCs has prognostic significance for the early post-transplant period. Optimization of medical therapy in these high-risk KTCs may improve post-transplant cardiovascular outcomes.