{Reference Type}: Journal Article
{Title}: The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus.
{Author}: Smith MA;Armas SP;Camp JD;Carlson HN;
{Journal}: Psychopharmacology (Berl)
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 12
{Factor}: 4.415
{DOI}: 10.1007/s00213-024-06648-z
{Abstract}: <B>BACKGROUND: </B>Preclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies have used same-sex dyads exclusively, and the role of factors related to biological sex and hormonal fluctuations are not well understood.<BR><B>OBJECTIVE: </B>The purpose of this study was to examine the reinforcing effects of cocaine and social contact with an opposite-sex partner in male and female rats, and how these effects are modulated by ovarian hormones.<BR><B>METHODS: </B>Male and female rats were trained in a nonexclusive choice procedure in which cocaine and social contact with an opposite-sex partner were simultaneously available on concurrent progressive ratio schedules of reinforcement. To examine the effects of ovarian hormones related to estrous cycling, Experiment 1 used naturally cycling, gonadally intact females, whereas Experiment 2 used ovariectomized females, and estrus was artificially induced with exogenous hormones.<BR><B>RESULTS: </B>In both experiments, cocaine and social contact functioned as robust reinforcers, and there were no significant effects of biological sex or estrus status of the females. The positive reinforcing effects of both cocaine and social contact increased as a function of cocaine dose, indicating that contingent cocaine administration increases the reinforcing effects of social contact.<BR><B>CONCLUSIONS: </B>These data suggest that cocaine use among opposite-sex partners may enhance factors that contribute to social bonding.