{Reference Type}: Journal Article {Title}: A crisis in clinical research. {Author}: Hong DS;LoRusso P;Sznol M; {Journal}: J Immunother Cancer {Volume}: 12 {Issue}: 7 {Year}: 2024 Jul 11 {Factor}: 12.469 {DOI}: 10.1136/jitc-2023-008520 {Abstract}: The clinical research pipeline is critical to ensuring continued development of novel treatments that can offer patients with cancer safe and effective options. Unfortunately, progress has slowed since the COVID-19 pandemic due to uncovered, systemic inefficiencies across critical processes. Towards initiating discussion on how to reinvigorate clinical research, the Society for Immunotherapy of Cancer (SITC) hosted a virtual summit that characterized issues and formed potential solutions. This commentary serves to highlight the crisis facing clinical research as well as stimulate field-wide discussion on how to better serve patients into the future.