{Reference Type}: Case Reports
{Title}: Systemic capillary leak syndrome in a patient treated with nivolumab/ipilimumab immunotherapy for metastatic melanoma with concurrent COVID-19 vaccination.
{Author}: Tan A;Polkinghorne A;Branley J;
{Journal}: BMJ Case Rep
{Volume}: 17
{Issue}: 7
{Year}: 2024 Jul 11
暂无{DOI}: 10.1136/bcr-2024-259875
{Abstract}: Systemic capillary leak syndrome (SCLS) is a rare and life-threatening disorder characterised by leaking of intravascular fluid to extravascular tissues. An association with immunotherapy and COVID-19 vaccination has been reported as potential triggers. A case of a patient in her 70s developing SCLS after the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination with a history of metastatic melanoma treated with nivolumab (PD-1 monoclonal antibody) and ipilimumab (anti-CTLA4 monoclonal antibody) is reported. The aetiology and management of SCLS are also reviewed in this case context.