{Reference Type}: Journal Article
{Title}: Six-year evaluation of device-associated nosocomial infections in intensive care units.
{Author}: Mert D;Çalışkan Demirkıran B;İskender G;Avşar Z;Timuroğlu A;Binay S;Aşkın T;Ertek M;
{Journal}: J Infect Dev Ctries
{Volume}: 18
{Issue}: 6
{Year}: 2024 Jun 30
{Factor}: 2.552
{DOI}: 10.3855/jidc.19426
{Abstract}: <B>BACKGROUND: </B>Invasive device-associated nosocomial infections commonly occur in intensive care units (ICUs). These infections include intravascular catheter-related bloodstream infection (CRBSI), ventilator-associated pneumonia (VAP), and catheter-associated urinary tract infection (CAUTI). This study aimed to evaluate the factors associated with invasive device-associated nosocomial infections based on the underlying diseases of the patients and antibiotic resistance profiles of the pathogens causing the infections detected in the ICU in our hospital over a five-year period.<BR><B>METHODS: </B>Invasive device-associated infections (CRBSI, VAP, and CAUTI) were detected retrospectively by the laboratory- and clinic-based active surveillance system according to the criteria of the US Centers for Disease Control and Prevention (CDC) in patients hospitalized in the ICU of the tertiary hospital between 1 January 2018 and 30 June 2023.<BR><B>RESULTS: </B>A total of 425 invasive device-associated nosocomial infections and 441 culture results were detected (179 CRBSI, 176 VAP, 70 CAUTI). Out of them, 57 (13.4%) patients had hematological malignancy, 145 (34.1%) had solid organ malignancy, and 223 (52.5%) had no histopathologic diagnosis of any malignancy. An increase in extended-spectrum beta lactamase (ESBL) and carbapenem resistance in pathogens was detected during the study period.<BR><B>CONCLUSIONS: </B>Antibiotic resistance of the Gram-negative bacteria associated with invasive device-associated infections increased during the study period. Antimicrobial stewardship will reduce rates of nosocomial infections, reduce mortality, and shorten hospital stay. Long-term catheterization and unnecessary antibiotic use should be avoided.