{Reference Type}: Case Reports
{Title}: Reevaluating Diagnosis of Sarcoidosis: Biopsy with Necrosis in Mycobacterial Endemic Areas.
{Author}: Manwatkar AA;Das JK;Issac NPR;Kothapalli N;Chandhu AS;Prabhu V;Mathew J;
{Journal}: J Assoc Physicians India
{Volume}: 72
{Issue}: 7
{Year}: 2024 Jul
暂无{DOI}: 10.59556/japi.72.0509
{Abstract}: <B>BACKGROUND: </B>Sarcoidosis is a multisystem inflammatory disease with a variable presentation. The most characteristic feature of sarcoidosis is nonnecrotizing granulomas. However, when sarcoidosis presents with rare organ involvement, and biopsy shows necrosis, the diagnosis becomes challenging.<BR><B>METHODS: </B>Here, we present three cases of sarcoidosis with unusual organ involvement and biopsy findings of necrosis, leading to a delay in diagnosis and treatment. Case 1 was presented with lymphoreticular involvement within the intraparotid lymph node and genitourinary area. Biopsy from the epididymis showed necrosis, initially leading to treatment for tuberculosis (TB). Case 2 describes lymphoreticular involvement and cardiac symptoms. His cervical and bone marrow biopsies showed necrosis. Case 3's presentation was disseminated lymphadenopathy with hepatosplenomegaly, initially suspected as malignancy or TB.<BR><B>CONCLUSIONS: </B>While biopsy plays a significant role in diagnosing sarcoidosis, the presence of necrosis alone should not lead to its exclusion.