{Reference Type}: Journal Article
{Title}: Hormone replacement therapy and myocardial infarction and stroke in postmenopausal Korean women.
{Author}: Baek JK;Kim HY;Kang MJ;Choi EA;Lee JK;Kim EH;Seo SK;
{Journal}: Climacteric
{Volume}: 27
{Issue}: 4
{Year}: 2024 Aug 19
{Factor}: 3.024
{DOI}: 10.1080/13697137.2024.2354728
{Abstract}: <B>UNASSIGNED: </B>This study aimed to investigate the association of hormone replacement therapy (HRT) use, type, duration and age of commencement with myocardial infarction (MI) and stroke in postmenopausal Korean women.<BR><B>UNASSIGNED: </B>This nested case-control study used data from the National Health Insurance Service database to analyze 2017 data from women aged ≥50 years and diagnosed with natural menopause between 2004 and 2007. Among 356,160 eligible women, 36,446 used HRT for ≥1 year and 319,714 did not (controls). These two groups were matched 1:1 for statistical analysis. Type and duration were categorized into three categories.<BR><B>UNASSIGNED: </B>Women who started estrogen-progestogen therapy (EPT) or estrogen therapy (ET) in their 50s, or EPT or tibolone in their ≥60s exhibited a lower stroke risk than controls. MI risk was lower among women who used tibolone - regardless of duration - or EPT or ET for 1-3 years than among controls. Stroke risk was lower with tibolone use for ≥5 years or with EPT or ET use for 1-3 years or ≥5 years than non-users.<BR><B>UNASSIGNED: </B>Our study may support the beneficial effect of HRT by showing that Korean postmenopausal women who used HRT at a relatively younger and healthier age had a relative benefit for MI and stroke.