{Reference Type}: Journal Article
{Title}: Diabetes with GLP-1R polymorphism (rs3765467) accompanied by myotonic dystrophy: A case of myotonic dystrophy with p.R131Q polymorphism at the glucagon-like peptide-1 receptor (rs3765467) resulting in marked effects of its agonist, dulaglutide.
{Author}: Kato K;Jojima T;Kogai T;Tanuma D;Niitani T;Sakurai S;Iijima T;Tomaru T;Usui I;Aso Y;
{Journal}: Am J Med Sci
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 8
{Factor}: 3.462
{DOI}: 10.1016/j.amjms.2024.06.030
{Abstract}: A 47-year-old woman was diagnosed with myotonic dystrophy when admitted for traumatic subarachnoid hemorrhage. Her glycemic control was poor despite administration of pioglitazone, a PPARɤ agonist, and subcutaneous insulin infusion. However, adding a GLP-1 receptor (GLP-1R) agonist markedly improved blood glucose levels, resulting in eventual insulin withdrawal. Genetic testing revealed a heterozygous variant, p.R131Q, in the GLP1R (rs3765467), a common variant in Asia. This variant is known to be associated with increased endogenous insulin from beta cells in response to exogenous GLP-1 infusion. This is the first report and short review of a Japanese case of myotonic dystrophy accompanied by GLP-1R gene polymorphism.