{Reference Type}: Journal Article
{Title}: Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.
{Author}: Ulugut H;Bertoux M;Younes K;Montembeault M;Fumagalli GG;Samanci B;Illán-Gala I;Kuchcinski G;Leroy M;Thompson JC;Kobylecki C;Santillo AF;Englund E;Waldö ML;Riedl L;Van den Stock J;Vandenbulcke M;Vandenberghe R;Laforce R;Ducharme S;Pressman PS;Caramelli P;de Souza LC;Takada LT;Gurvit H;Hansson O;Diehl-Schmid J;Galimberti D;Pasquier F;Miller BL;Scheltens P;Ossenkoppele R;van der Flier WM;Barkhof F;Fox NC;Sturm VE;Miyagawa T;Whitwell JL;Boeve B;Rohrer JD;Gorno-Tempini ML;Josephs KA;Snowden J;Warren JD;Rankin KP;Pijnenburg YAL; ;
{Journal}: Alzheimers Dement
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 10
{Factor}: 16.655
{DOI}: 10.1002/alz.14076
{Abstract}: <B>BACKGROUND: </B>Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.<BR><B>METHODS: </B>Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.<BR><B>RESULTS: </B>Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.<BR><B>CONCLUSIONS: </B>This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.<BR><B>CONCLUSIONS: </B>This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.