{Reference Type}: Journal Article
{Title}: The effect of BIS-guided anaesthesia on the incidence of postoperative nausea and vomiting in children: a prospective randomized double-blind study.
{Author}: Frelich M;Sklienka P;Romanová T;Němcová S;Bílená M;Straková H;Lečbychová K;Jor O;Formánek M;Burša F;
{Journal}: BMC Anesthesiol
{Volume}: 24
{Issue}: 1
{Year}: 2024 Jul 9
{Factor}: 2.376
{DOI}: 10.1186/s12871-024-02610-w
{Abstract}: <B>BACKGROUND: </B>Postoperative nausea and vomiting (PONV) is a significant problem following paediatric surgery, and volatile anaesthetics are an important cause of this phenomenon. BIS-guided anaesthesia, by reducing the consumption of anaesthetics, leads to a decrease in PONV in adult patients.<BR><B>OBJECTIVE: </B>Evaluate the role of BIS-guided anaesthesia in reducing the incidence of paediatric PONV.<BR><B>METHODS: </B>Prospective, randomized, double-blind study.<BR><B>METHODS: </B>A single center study in university hospital in Czech republic, from June 2021 to November 2022.<BR><B>METHODS: </B>A total of 163 children, aged 3-8 years with ASA I-II who underwent endoscopic adenoidectomy under general anaesthesia were included.<BR><B>METHODS: </B>In the intervention group, the depth of anaesthesia was maintained to values between 40 and 60 of BIS.<BR><B>METHODS: </B>The primary outcome was the incidence of postoperative nausea and vomiting during 24 h after surgery.<BR><B>RESULTS: </B>The use of BIS-guided anaesthesia led to a significant decrease in the incidence of nausea and vomiting compared to the control group [17% vs. 53%; RR (95%CI) 0.48 (0.27-0.86); p < 0.001and 16% vs. 34%; RR (95%CI) 0.33 (0.20-0.54); p = 0.01, respectively].<BR><B>CONCLUSIONS: </B>BIS-guided anaesthesia decreases the incidence of postoperative nausea and vomiting in children undergoing adenoidectomy.<BR><B>BACKGROUND: </B>Clinicaltrials.gov identifier: NCT04466579.