{Reference Type}: Journal Article
{Title}: Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination.
{Author}: Lise V;Malenica I;Roychoudhuri R;Lugli E;
{Journal}: Cancer Cell
{Volume}: 42
{Issue}: 7
{Year}: 2024 Jul 8
{Factor}: 38.585
{DOI}: 10.1016/j.ccell.2024.06.010
{Abstract}: In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exert potent effector functions and eradicate established solid tumors.