{Reference Type}: Journal Article {Title}: Leveraging Multiomics Insights and Exploiting Wild Relatives' Potential for Drought and Heat Tolerance in Maize. {Author}: Jamil S;Ahmad S;Shahzad R;Umer N;Kanwal S;Rehman HM;Rana IA;Atif RM; {Journal}: J Agric Food Chem {Volume}: 72 {Issue}: 29 {Year}: 2024 Jul 24 {Factor}: 5.895 {DOI}: 10.1021/acs.jafc.4c01375 {Abstract}: Climate change, particularly drought and heat stress, may slash agricultural productivity by 25.7% by 2080, with maize being the hardest hit. Therefore, unraveling the molecular nature of plant responses to these stressors is vital for the development of climate-smart maize. This manuscript's primary objective was to examine how maize plants respond to these stresses, both individually and in combination. Additionally, the paper delved into harnessing the potential of maize wild relatives as a valuable genetic resource and leveraging AI-based technologies to boost maize resilience. The role of multiomics approaches particularly genomics and transcriptomics in dissecting the genetic basis of stress tolerance was also highlighted. The way forward was proposed to utilize a bunch of information obtained through omics technologies by an interdisciplinary state-of-the-art forward-looking big-data, cyberagriculture system, and AI-based approach to orchestrate the development of climate resilient maize genotypes.