{Reference Type}: Journal Article {Title}: Interaction between spiders and ticks-ancient arthropod predatory behavior? {Author}: de la Fuente J;Estrada-Peña A;Labruna MB;Szabó MPJ; {Journal}: Parasitol Res {Volume}: 123 {Issue}: 7 {Year}: 2024 Jul 9 {Factor}: 2.383 {DOI}: 10.1007/s00436-024-08282-2 {Abstract}: Ticks are ectoparasite vectors of pathogens affecting human and animal health worldwide. Rational integration of different control interventions including plant-derived repellents and acaricides, management of natural predators, and vaccines is required for innovative approaches to reduce the risks associated with ticks and tick-borne diseases. How tick populations are naturally controlled is always a question. Tick interactions with other arthropods including predators evolved from ancient times. In this study, Cretaceous (ca. 100 Mya) Burmese amber inclusions were identified as probably related to Compluriscutula vetulum (Acari: Ixodida: Ixodidae) tick larvae and spider silk. As illustrated in this study, ancient interactions between ticks and spiders may support arthropod predatory behavior as a natural control intervention. Rational integrative management of different tick control interventions including natural predators under a One Health perspective will contribute to effectively and sustainably reducing the risks associated with ticks and tick-borne diseases.