{Reference Type}: Journal Article
{Title}: Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat.
{Author}: Wang XH;Dong PF;Wang F;Zhou L;
{Journal}: J Asian Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 9
{Factor}: 1.61
{DOI}: 10.1080/10286020.2024.2375291
{Abstract}: In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.