{Reference Type}: Journal Article
{Title}: Keratin 17 and Collagen type 1 genes: Esophageal cancer molecular marker discovery and evaluation.
{Author}: Pan H;Hong J;Shao A;Zhao Z;Ding G;Fang Z;Chen K;Zhu J;
{Journal}: Clin Respir J
{Volume}: 18
{Issue}: 7
{Year}: 2024 Jul
{Factor}: 1.761
{DOI}: 10.1111/crj.13793
{Abstract}: One hundred eighty pairs of tissues of esophageal squamous cell carcinoma (ESCC) were tested by the transcriptome sequencing in order to explore etiology factors. The chi-square test and correlation analysis demonstrated that the relative expression levels of keratin 17 (KRT17) and collagen type I α1 chain (COL1A1) were significantly higher in EC with diabetes. Expression of KRT17 was correlated with blood glucose (r = 0.204, p = 0.001) and tumor size (r = -0.177, p = 0.038) in patients. COL1A1 correlated with age (r = -0.170, p = 0.029) and blood glucose levels (r = 0.190, p = 0.015). Experimental results of qRT-PCR: KRT17 and COL1A1 genes were highly expressed in ESCC (p < 0.05). When the two genes were used as a combination test, the positive detection rate of EC was 90.6%, and the ROC curve had greater power. The KRT17 and COL1A1 genes had the potential to be biomarkers for the diagnosis of ESCC.