{Reference Type}: Journal Article
{Title}: GATA2 deficiency syndrome: A compensatory mechanism gone awry?
{Author}: Rio-Machin A;
{Journal}: Br J Haematol
{Volume}: 205
{Issue}: 2
{Year}: 2024 Aug 8
{Factor}: 8.615
{DOI}: 10.1111/bjh.19638
{Abstract}: In their paper, using zebrafish models, Gioacchino et al. have demonstrated the GATA2 haploinsufficiency, the genetic hallmark of GATA2 deficiency syndrome, promotes erythroid and myeloid cytopenia, and have discovered a self-regulatory mechanism to compensate GATA2 levels and protein function. Commentary on: Gioacchino et al. GATA2 heterozygosity causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia. Br J Haematol 2024;205:580-593.