{Reference Type}: Journal Article
{Title}: Influence of easing COVID-19 strategies following downgrading of the national infectious disease category on COVID-19 occurrence among hospitalized patients in Japan.
{Author}: Makino M;Takesue Y;Murakami Y;Morosawa M;Doi M;Ogashiwa H;Ueda T;Nakajima K;Sugiura H;Nozaki Y;
{Journal}: J Infect Chemother
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 6
{Factor}: 2.065
{DOI}: 10.1016/j.jiac.2024.07.004
{Abstract}: <B>OBJECTIVE: </B>We aimed to evaluate the influence of easing COVID-19 preventive measures following its downgrading to a common infectious disease on COVID-19 occurrence among hospitalized patients.<BR><B>METHODS: </B>Nosocomial occurrence of COVID-19 was compared between periods with national infectious disease category 5 versus the preceding category 2 equivalent. Changes in the revised manual included a shorter duration of work restrictions for infected health care practitioners (HCPs); no work restriction for HCPs exposed to SARS-CoV-2 with a negative test on days 1, 3 and 5; discontinuation of universal pre-admission screening; and pre-emptive isolation of patients without screening. Wearing an N95 mask and face shield was required in procedure/care with moderate-to high-risk contact.<BR><B>RESULTS: </B>Although the mean monthly number of infected HCPs increased from 8.1 to 12.7 in the category 5 period (p = 0.034) and that of pre-admission screening decreased to one-fourth, the COVID-19 incidence in hospitalized patients remained similar between the two study periods (1.60 ± 5.59/month versus 1.40 ± 2.63/month, p = 0.358). Clusters, defined as ≥3 COVID-19 patients on the ward, were experienced twice in the preceding period and only once in the category 5 period. The index cases causing nosocomial SARS-CoV-2 transmission mostly involved rehabilitation therapists in the preceding period; five of six index cases were patients in the category 5 period. Following the expanded indication for N95 masks, neither SARS-CoV-2 transmission to patients nor transmission from infected patients was observed in HCPs for 1 year.<BR><B>CONCLUSIONS: </B>With sustained, enhanced standard precautions, easing prevention strategies could limit nosocomial SARS-CoV-2 infections.