{Reference Type}: Case Reports
{Title}: Screening and surveillance of hepatocellular carcinoma by serum des-gamma-carboxy prothrombin in patients with glycogen storage disease type Ia.
{Author}: Schreuder AB;Overduin RJ;Peltenburg NC;de Boer L;Bodewes FAJA;Derks TGJ;
{Journal}: JIMD Rep
{Volume}: 65
{Issue}: 4
{Year}: 2024 Jul
暂无{DOI}: 10.1002/jmd2.12414
{Abstract}: No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.