{Reference Type}: Journal Article
{Title}: Feasibility and safety of peroral endoscopic myotomy with fundoplication in patients with achalasia: a systematic review and meta-analysis.
{Author}: Kamal F;Khan MA;Lee-Smith W;Sharma S;Acharya A;Farooq U;Ejaz Z;Aziz M;Gangwani MK;Hayat U;Kumar A;Schlachterman A;Loren D;Kowalski T;
{Journal}: Ann Gastroenterol
{Volume}: 37
{Issue}: 4
{Year}: 2024 Jul-Aug
暂无{DOI}: 10.20524/aog.2024.0890
{Abstract}: <B>UNASSIGNED: </B>Achalasia can cause disabling symptoms that may substantially impair the quality of life. Peroral endoscopic myotomy (POEM) has shown promising results in the management of achalasia. In this meta-analysis we have evaluated the feasibility and safety of single-session POEM with fundoplication (POEM+F) in patients with achalasia.<BR><B>UNASSIGNED: </B>We reviewed several databases from inception to July 08, 2022, to identify studies evaluating the feasibility and/or safety of single-session POEM+F for patients with achalasia. Our outcomes of interest included the technical success of POEM+F, adverse events, esophagitis and wrap integrity on follow-up upper endoscopy, total procedure time, and fundoplication time. Pooled rates with 95% confidence intervals (CI) for outcomes were calculated using a random effect model. Heterogeneity was assessed using the I 2 statistic.<BR><B>UNASSIGNED: </B>We included 4 studies with 90 patients. Pooled rates (95%CI) of technical success and adverse events were 92% (83-96%) and 5% (2-11%), respectively. Pooled rates (95%CI) of esophagitis and wrap integrity on follow-up upper endoscopy were 18% (11-30%) and 85% (43-98%) respectively. Pooled mean procedure time and fundoplication time were 113.2 (98.7-127.6) and 55.3 (43.7-66.8) min, respectively.<BR><B>UNASSIGNED: </B>This meta-analysis demonstrates the feasibility and safety of POEM+F in patients with achalasia. More studies with long-term follow up are required to further validate these findings.