{Reference Type}: Journal Article
{Title}: Multiple pandemic waves vs multi-period/multi-phasic epidemics: Global shape of the COVID-19 pandemic.
{Author}: d'Onofrio A;Iannelli M;Marinoschi G;Manfredi P;
{Journal}: J Theor Biol
{Volume}: 593
{Issue}: 0
{Year}: 2024 Oct 7
{Factor}: 2.405
{DOI}: 10.1016/j.jtbi.2024.111881
{Abstract}: The overall course of the COVID-19 pandemic in Western countries has been characterized by complex sequences of phases. In the period before the arrival of vaccines, these phases were mainly due to the alternation between the strengthening/lifting of social distancing measures, with the aim to balance the protection of health and that of the society as a whole. After the arrival of vaccines, this multi-phasic character was further emphasized by the complicated deployment of vaccination campaigns and the onset of virus' variants. To cope with this multi-phasic character, we propose a theoretical approach to the modeling of overall pandemic courses, that we term multi-period/multi-phasic, based on a specific definition of phase. This allows a unified and parsimonious representation of complex epidemic courses even when vaccination and virus' variants are considered, through sequences of weak ergodic renewal equations that become fully ergodic when appropriate conditions are met. Specific hypotheses on epidemiological and intervention parameters allow reduction to simple models. The framework suggest a simple, theory driven, approach to data explanation that allows an accurate reproduction of the overall course of the COVID-19 epidemic in Italy since its beginning (February 2020) up to omicron onset, confirming the validity of the concept.