{Reference Type}: Journal Article
{Title}: Echocardiography Core Laboratory Methodology for TAVR: A Transatlantic Consensus.
{Author}: Ren CB;Tardif D;Brandenburg HJ;Roux M;Mrevlje B;Geleijnse ML;Van Mieghem NM;Spitzer E;Pibarot P;
{Journal}: JACC Cardiovasc Imaging
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 20
{Factor}: 16.051
{DOI}: 10.1016/j.jcmg.2024.04.014
{Abstract}: Inter-echocardiography core laboratory (ECL) harmonization is pivotal to consider data from different ECLs interchangeable. On the basis of the experience of the first trans-Atlantic harmonization of 2 established ECLs in the field of transcatheter aortic valve replacement (TAVR) trials, this review describes the harmonized ECL methodology in analyzing and adjudicating the post-TAVR echocardiographic endpoints according to Valve Academic Research Consortium 3 definitions. This review presents the feasibility and intra- and inter-ECL reproducibility, explains the root cause of potential important inter-ECL variability, and formulates ECL recommendations for optimal post-TAVR echocardiographic image acquisition. The implementation of inter-ECL harmonization may further define the best practice of ECLs and have logistic and regulatory implications for the realization of future TAVR trials.