{Reference Type}: Journal Article
{Title}: A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing.
{Author}: Han X;Zhang Y;Zhang Y;Song Q;Hasi W;Lin S;Wang F;
{Journal}: Anal Chim Acta
{Volume}: 1316
{Issue}: 0
{Year}: 2024 Aug 8
{Factor}: 6.911
{DOI}: 10.1016/j.aca.2024.342820
{Abstract}: This research presents an innovative reflective fiber optic probe structure, mutinously designed to detect H7N9 avian influenza virus gene precisely. This innovative structure skillfully combines multimode fiber (MMF) with a thin-diameter seven-core photonic crystal fiber (SCF-PCF), forming a semi-open Fabry-Pérot (FPI) cavity. This structure has demonstrated exceptional sensitivity in light intensity-refractive index (RI) response through rigorous theoretical and experimental validation. The development of a quasi-distributed parallel sensor array, which provides temperature compensation during measurements, has achieved a remarkable RI response sensitivity of up to 532.7 dB/RIU. The probe-type fiber optic sensitive unit, expertly functionalized with streptavidin, offers high specificity in detecting H7N9 avian influenza virus gene, with an impressively low detection limit of 10-2 pM. The development of this biosensor marks a significant development in biological detection, offering a practical engineering solution for achieving high sensitivity and specificity in light-intensity-modulated biosensing. Its potential for wide-ranging applications in various fields is now well-established.