{Reference Type}: Journal Article
{Title}: The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study.
{Author}: Sandes-Freitas TV;Moura LR;Carvalho DRBM;Garcia VD;Modelli de Andrade LG;Mazzali M;Manfro RC;Deboni LM;Davi-Neto E;Oliveira CMC;Cavalcanti FCB;Madeira RL;Esmeraldo RM;Simão DR;Meira ACG;Ferreira GF;Lasmar M;Bignelli AT;Pacheco-Silva A;Medina Pestana J;Tedesco Silva H; ;
{Journal}: PLoS One
{Volume}: 19
{Issue}: 7
{Year}: 2024
{Factor}: 3.752
{DOI}: 10.1371/journal.pone.0306056
{Abstract}: This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.