{Reference Type}: Journal Article
{Title}: Quercetin may reduce the risk of developing the symptoms of COVID-19.
{Author}: Ajami M;Sotoudeheian M;Houshiar-Rad A;Esmaili M;Naeini F;Mohammadi Nasrabadi F;Doaei S;Milani-Bonab A;
{Journal}: Avicenna J Phytomed
{Volume}: 14
{Issue}: 2
{Year}: 2024 Mar-Apr
暂无{DOI}: 10.22038/AJP.2023.22920
{Abstract}: <B>UNASSIGNED: </B>Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article.<BR><B>UNASSIGNED: </B>Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: "corona or coronavirus or COVID or COVID-19 or viral or virus" AND "nutrient or flavonoid or Quercetin".<BR><B>UNASSIGNED: </B>The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.<BR><B>UNASSIGNED: </B>Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted.