{Reference Type}: Journal Article {Title}: Optimizing pediatric periprocedural pain management part II-Adjunct therapies to support the use of infiltrative anesthetics. {Author}: Henkel ED;Haller CN;Diaz LZ;Ricles V;Wong Grossman AV;Nemergut ME;Krakowski AC; {Journal}: Pediatr Dermatol {Volume}: 0 {Issue}: 0 {Year}: 2024 Jul 4 {Factor}: 1.997 {DOI}: 10.1111/pde.15677 {Abstract}: Pediatric procedure-related pain management is often incompletely understood, inadequately addressed, and critical in influencing a child's lifelong relationship with the larger healthcare community. We present a comprehensive review of infiltrative anesthetics, including a comparison of their mechanisms of action and relative safety and efficacy data to help guide clinical selection. We also describe the multimodal utilization of adjunct therapies-in series and in parallel-to support the optimization of pediatric periprocedural pain management, enhance the patient experience, and provide alternatives to sedation medication and general anesthesia.