{Reference Type}: Journal Article
{Title}: Incidence of and risk factors for paediatric perioperative anaphylaxis in the USA.
{Author}: Krase IZ;Rukasin CRF;Sacco K;Rank MA;Volcheck GW;Gonzalez-Estrada A;
{Journal}: Br J Anaesth
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 3
{Factor}: 11.719
{DOI}: 10.1016/j.bja.2024.05.025
{Abstract}: <B>BACKGROUND: </B>Perioperative anaphylaxis is a serious and often life-threatening immediate hypersensitivity reaction. There are few published data on paediatric perioperative anaphylaxis (pPOA). We evaluated the incidence of and risk factors involved in the occurrence of pPOA within a large US national database.<BR><B>METHODS: </B>Deidentified data from the US Nationwide Inpatient Sample from 2005 to 2014 were used to identify pPOA cases and to conduct a retrospective multivariate analysis of preselected independent variables.<BR><B>RESULTS: </B>Among 3,601,180 surgeries and procedures in children aged 0-18 yr, 297 pPOA cases were identified for an incidence of one in 12,125 surgeries and procedures. Compared with controls, pPOA cases had an increased median length of stay (6 vs 2 days; P<0.001) and median hospital cost ($54 719 vs $5109; P<0.0001). The age groups between 6 and 12 yr (odds ratio [OR] 7.1; 95% confidence interval [CI] 3.9-12.9; P<0.001) and 13 and 17 yr (OR 8.5; 95% CI 4.7-15.2; P<0.001) were associated with increased odds of pPOA. Transplant (OR 46.3; 95% CI 20.8-102.9; P<0.001), cardiac (OR 16.4; 95% CI 7.5-35.9; P<0.001), and vascular (OR 15.2; 95% CI 7.5-30.7; P<0.001) procedures posed the highest risk for pPOA. Chronic pulmonary disease, coagulopathy, and fluid and electrolyte disorders were also associated with pPOA (OR 2.2; 95% CI 1.5-3.3; P<0.001).<BR><B>CONCLUSIONS: </B>The incidence of pPOA was one in 12,125 cases. Risk factors included age, procedure type, and comorbidities.