{Reference Type}: Journal Article
{Title}: Heptaellipside A, a rare new 2,28-bidesmosidic lupane-type saponin from the leaves of Heptapleurum ellipticum.
{Author}: Ngo TN;Nguyen TA;Huynh NT;Ly HD;Dang THN;Nguyen TKP;Huynh KY;Dang VS;Nguyen QH;Ngo QL;Do THT;Dung Hoang TK;Nguyen TP;
{Journal}: Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 4
{Factor}: 2.488
{DOI}: 10.1080/14786419.2024.2375311
{Abstract}: For the first time, phytochemical constituents of the leaves of Heptapleurum ellipticum were investigated. One rare new 2,28-bidesmosidic lupane-type saponin, named heptaellipside A (1), along with four other lupane-type analogs (2-5) were purified by combining differently chromatographic methods. All of the separated compounds (1-5) were communicated for the first time from H. ellipticum. The structures of them were definitely illustrated following extensive and comprehensive UV/VIS, FTIR, HRMS/ESI, and NMR techniques. Further, all isolated compounds were evaluated for their α-glucosidase and α-amylase inhibition. As the results, compound 3 respectively exhibited stronger in both inhibitory activities against α-glucosidase and α-amylase (IC50 values of 15.53 and 26.93 μM), than the acarbose standard (IC50 values of 214.50 and 143.48 μM).